If you’re struggling with depression, you may already be familiar with traditional antidepressants. They’ve been the go-to treatment for decades, helping millions of people manage their symptoms. However, they don’t work for everyone, and they often take several weeks to start working.

In contrast, ketamine therapy has recently gained popularity for its ability to provide fast relief, especially in people with depression.

Below, we’ll break down the key differences between traditional antidepressants and ketamine therapy, including how they work, how effective they are, who might benefit from each, and how to find a reputable ketamine clinic in New Hampshire.


Traditional Antidepressants: The First Line of Defense
Traditional antidepressants remain the most common treatment for depression. They are usually the first option doctors prescribe because they are backed by decades of research and have proven effective for many people. While they can be life-changing for some, they also come with limitations, including delayed onset of action and potential side effects.


How Traditional Antidepressants Work
Traditional antidepressants mainly fall into two categories: selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs). These medications work by increasing the levels of serotonin and/or norepinephrine in the brain, two key neurotransmitters involved in mood regulation. SSRIs, such as Prozac and Zoloft, block the reabsorption of serotonin, leaving more available in the brain to improve communication between neurons. SNRIs, like Effexor and Cymbalta, do the same but also affect norepinephrine, which can boost energy and help with stress.

The goal of these medications is to restore balance in brain chemistry, helping to stabilize mood, reduce anxiety, and improve overall emotional well-being.



How Long Do Traditional Antidepressants Take to Work?
One of the major downsides of traditional antidepressants is how long they take to produce noticeable effects. For most people, it can take anywhere from 4 to 6 weeks to experience significant symptom relief. This can be difficult for individuals dealing with severe depression or those at risk of suicide, as the waiting period can feel interminable.

Additionally, not everyone responds to the first medication they try. Many patients must go through multiple trials to find the right medication or combination of medications. Roughly 30% of people with depression are considered to have depression, meaning they don’t respond adequately to traditional antidepressants.
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How Effective Are Traditional Antidepressants?
When traditional antidepressants work, they can be highly effective. Studies show that about 60-70% of people respond positively to antidepressants after trying one or more medications. However, around 30-40% of patients may not experience sufficient relief, even after several medication trials.

In addition to delayed effectiveness, antidepressants come with side effects that can be hard to manage. Common side effects include nausea, weight gain, sexual dysfunction, insomnia, and increased anxiety during the first few weeks of treatment. These issues can cause some people to stop taking their medication before it has a chance to work, leading to a relapse of symptoms.

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​Who Is a Good Candidate for Traditional Antidepressants?
​Traditional antidepressants are typically recommended as the first line of treatment for people with mild to moderate depression. They’re a good option for individuals who:
      - Have never tried antidepressants before
      - Are dealing with mild to moderate depression
      - Can wait several weeks for the medication to take effect
      - Want a treatment option that’s widely available and well-researched

Since traditional antidepressants are affordable and have a long track record of success, they’re often the best starting point for most patients.

Ketamine Therapy: A Rapid Solution for Severe Depression

Ketamine therapy offers a promising alternative for individuals who haven’t found success with traditional antidepressants. Originally developed as an anesthetic, ketamine has shown impressive antidepressant effects. What sets ketamine apart is its fast-acting nature—many patients report feeling relief within hours or days of their first infusion.

How Ketamine Therapy Works
​Unlike traditional antidepressants, which target serotonin and norepinephrine, ketamine works by modulating glutamate, the brain’s main excitatory neurotransmitter. Glutamate plays a critical role in synaptic plasticity, or the brain’s ability to form new neural connections.

Ketamine is an NMDA receptor antagonist, meaning it blocks certain receptors in the brain, leading to a surge in glutamate activity. This increase in glutamate helps the brain form new pathways, which researchers believe is key to breaking the negative thought patterns associated with depression. By promoting neuroplasticity, ketamine may help patients “reset” their brain and adopt healthier ways of thinking and feeling.

How Long Does Ketamine Therapy Take to Work?
​One of the biggest advantages of ketamine therapy is how quickly it works. Many people report feeling significant relief within hours or a few days of their first treatment, making it a valuable option for individuals with severe depression or those experiencing suicidal thoughts.

Ketamine is typically administered as a series of intramuscular (IM) injections, IV infusions or sublingually over several weeks. Unlike traditional antidepressants, which require daily dosing, ketamine is given periodically in a clinical setting. Some patients may need occasional booster doses to maintain symptom relief over time.

How Effective Is Ketamine Therapy?
​Ketamine has shown remarkable effectiveness in treating depression, particularly for individuals who haven’t responded to traditional medications. Studies suggest that up to 70% of patients with depression experience significant symptom improvement after ketamine treatment.

However, ketamine isn’t without its risks. Common side effects include dissociation (feeling detached from reality), dizziness, nausea, and increased blood pressure. These side effects are usually short-lived, subsiding shortly after the infusion ends. There are also concerns about the potential for abuse, given ketamine’s history as a recreational drug. That’s why ketamine therapy should only be administered in a medical setting under the supervision of trained professionals.

Who Is a Good Candidate for Ketamine Therapy?
​Ketamine therapy may be a better option for individuals with severe depression, especially if they need fast relief. You might be a good candidate for ketamine therapy if:
      - You have depression and haven’t responded to multiple antidepressants
      - You’re experiencing severe depression with suicidal thoughts and need immediate symptom relief
      - You’re open to undergoing treatment in a clinical setting and can commit to a series of treatments
      - You understand the potential risks and benefits of ketamine therapy

Since ketamine works quickly and through a different mechanism than traditional antidepressants, it’s often recommended for those who haven’t found relief through other means.

How to Find a Reputable Ketamine Clinic
​If you’re considering ketamine therapy, choosing a reputable clinic is crucial to ensure safe and effective treatment. Start by ensuring the clinic has licensed medical professionals, such as psychiatrists, anesthesiologists, or nurse practitioners experienced in administering ketamine for mental health. A thorough evaluation process should be standard, including a psychiatric assessment, review of past treatments, and a physical health screening to confirm that ketamine is appropriate for you.

During treatment, reputable clinics provide close monitoring, tracking vital signs and managing any side effects. Post-treatment support, such as follow-up appointments and counseling, is also important to help you integrate the benefits of ketamine into your overall mental health plan. Additionally, ask about the clinic’s dosing protocols, administration methods, and emergency procedures to ensure proper safety standards.

Reviews and testimonials from other patients can offer valuable insights, but focus on detailed feedback that mentions specific aspects of care. Since insurance rarely covers ketamine for mental health, check if the clinic offers financing options or documentation for possible out-of-network reimbursement.

​Finally, look for clinics that emphasize mental health integration by combining ketamine therapy with psychotherapy or other supportive treatments. This holistic approach can improve long-term outcomes by addressing both immediate symptoms and underlying issues. Taking these steps will help you find a clinic that prioritizes safety, effectiveness, and comprehensive care.
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​Final Thoughts: Choosing the Right Treatment
​Both traditional antidepressants and ketamine therapy have their place in treating depression. Traditional antidepressants are often the first step for people with mild to moderate symptoms because they’re well-researched and widely accessible. On the other hand, ketamine therapy is a game-changer for individuals with severe depression who need fast relief.

If you believe you may benefit from ketamine therapy, the team at Blue Lotus Wellness is here to help. We offer ketamine-assisted psychotherapy and have helped hundreds of New Hampshirites overcome their depression, anxiety, and other mental health challenges.

​Click here to learn more about our ketamine therapy treatment options – including in-person ketamine treatments, take-home lozenge programs, group ketamine therapy, and multi-day ketamine retreats – or book your first appointment here to get started.
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